Orphanet: Hereditary cerebral hemorrhage with amyloidosis

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Hereditary cerebral hemorrhage with amyloidosis

Disease definition

Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.


Classification level: Disorder
  • Synonym(s):
    • HCHWA
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Adult
  • ICD-10: E85.4+  I68.0*
  • OMIM: 105150  605714
  • UMLS: C1510489
  • MeSH: -
  • GARD: 10266
  • MedDRA: -

Detailed information

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