Orphanet: Mal de Meleda

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Mal de Meleda

Disease definition

Mal de Meleda (MdM) is a diffuse palmoplantar keratoderma, initially reported in the Island of Meleda, characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgrediens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema.


Classification level: Disorder
  • Synonym(s):
    • Keratosis palmoplantaris transgrediens of Siemens
    • Meleda disease
    • Transgrediens palmoplantar keratoderma of Siemens
  • Prevalence: 1-9 / 100 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Neonatal, Infancy, Childhood
  • ICD-10: Q82.8
  • OMIM: 248300
  • UMLS: C0025221
  • MeSH: -
  • GARD: 92
  • MedDRA: -

Detailed information


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