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Landau-Kleffner syndrome

Disease definition

Landau-Kleffner syndrome (LKS) is an age-related epileptic encephalopathy where developmental regression occurs mainly in the language domain and the electroencephalographic (EEG) abnormalities are mainly localized around the temporal-parietal regions. The term acquired epileptic aphasia describes the main features of this condition.

ORPHA:98818

Classification level: Disorder
  • Synonym(s):
    • Acquired epileptic aphasia
    • LKS
  • Prevalence: -
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood
  • ICD-10: F80.3
  • OMIM: 245570
  • UMLS: C0282512
  • MeSH: D018887
  • GARD: 6855
  • MedDRA: 10052075

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