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Progressive hemifacial atrophy

Disease definition

Progressive hemifacial atrophy (PHA) is a rare acquired disorder, characterized by unilateral slowly progressive atrophy of the skin and soft tissues of half of the face leading to a sunken appearance. Muscles, cartilage and the underlying bony structures may also be involved.


  • Synonym(s):
    • Hemifacial atrophy
    • PHA
    • Parry-Romberg syndrome
    • Progressive facial hemiatrophy
    • Romberg syndrome
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Childhood, Adolescent, Adult
  • ICD-10: G51.8
  • OMIM: 141300
  • UMLS: C0015458
  • MeSH: -
  • GARD: 7338
  • MedDRA: -

Detailed information


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