x

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.

Attention

Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Orphanet doesn't provide personalised answers. To get in touch with the Orphanet team, please contact

Information provided in your contribution (including your email address) will be stocked in .CSV files that will be sent as an email to Orphanet's teams. These emails might be conserved in the teams' mailboxes, in our backoffice servers but will not be registered in our databases (for more information see our section General Data Protection Regulation and data privacy (GDPR) and Confidentiality).

Captcha image

Mild hemophilia A

Disease definition

Mild hemophilia A is a form of hemophilia A (see this term) characterized by a small deficiency of factor VIII leading to abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction.

ORPHA:169808

Classification level: Subtype of disorder
  • Synonym(s):
    • Mild factor VIII deficiency
  • Prevalence: -
  • Inheritance: X-linked recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: D66
  • OMIM: 306700
  • UMLS: C0272324
  • MeSH: -
  • GARD: -
  • MedDRA: -

Summary

Epidemiology

Mild hemophilia A accounts for around 40% of all cases of hemophilia A.

Clinical description

The biological activity of factor VIII is between 5 and 40%. Spontaneous hemorrhages do not occur.

Etiology

The disorder is caused by mutations in the F8 gene (Xq28) encoding coagulation factor VIII.

Genetic counseling

Transmission is X-linked recessive.

Expert reviewer(s):  Pr Claude NEGRIER - Last update: May 2009

Detailed information

Article for general public

Professionals

Additional information

Further information on this disease

Patient-centred resources for this disease

Research activities on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.