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Herpes simplex virus encephalitis

Disease definition

A rare disorder caused by infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. This disorder often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness.

ORPHA:1930

Classification level: Disorder
  • Synonym(s):
    • HSE
    • HSV encephalitis
    • HSVE
    • Herpes simplex meningo-encephalitis
    • Herpes simplex neuroinvasion
    • Herpetic encephalitis
  • Prevalence: Unknown
  • Inheritance: Not applicable or Multigenic/multifactorial 
  • Age of onset: All ages
  • ICD-10: B00.4+  G05.1*
  • OMIM: 610551  613002  614849  614850  616532  617900
  • UMLS: C0019385  C0276226
  • MeSH: -
  • GARD: 6649
  • MedDRA: -

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