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Usher syndrome type 2

Disease definition

A rare ciliopathy characterized by congenital moderate-to-severe deafness, retinitis pigmentosa developing in the first or second decade, and normal vestibular function. Congenital bilateral sensorineural hearing loss is mild to moderate in the low frequencies and severe to profound in the higher frequencies. Additional manifestations include night blindness, constricted visual field (tunnel vision), and later on decreased visual acuity sometimes ending with bare light perception.

ORPHA:231178

Classification level: Subtype of disorder
  • Synonym(s):
    • USH2
  • Prevalence: 1-9 / 100 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: H35.5
  • OMIM: 276901  605472  611383
  • UMLS: C0339534  C1568249
  • MeSH: -
  • GARD: 5440
  • MedDRA: -

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