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Acute monoblastic leukemia

Disease definition

Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML; see this term) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).

ORPHA:514

Classification level: Disorder
  • Synonym(s):
    • AML M5
    • Acute monocytic leukemia
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Childhood
  • ICD-10: C92.7
  • OMIM: -
  • UMLS: C0023465  C0457334  C1318544
  • MeSH: D007948
  • GARD: 525
  • MedDRA: 10000871  10059439

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