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Macrophagic myofasciitis

Disease definition

A rare acquired skeletal muscle disease characterized by infiltration of the epimysium, perimysium, and perifascicular endomysium by macrophages with crystal inclusions composed of aluminum salts at the site of a previous vaccination (most commonly the deltoid muscle). Muscle necrosis is typically absent. Patients may present with myalgias, arthralgias, muscle weakness, chronic fatigue, asthenia, fever, and cognitive dysfunction. Signs and symptoms usually develop slowly over several months.

ORPHA:592

Classification level: Disorder
  • Synonym(s):
    • MMF
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Childhood, Adolescent, Adult, Elderly
  • ICD-10: M60.8
  • OMIM: -
  • UMLS: C2931639
  • MeSH: C537829
  • GARD: 176
  • MedDRA: -

  A summary on this disease is available in Español (2021) Français (2021) Nederlands (2021) Português (2021)

Additional information

Further information on this disease

Patient-centred resources for this disease

Research activities on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.