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Acute undifferentiated leukemia

Disease definition

A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells, primarily in the bone marrow and blood, lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis, anemia, variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (lymphadenopathy, splenomegaly, hepatomegaly).

ORPHA:98835

Classification level: Disorder
  • Synonym(s):
    • Acute myeloid leukemia, minimal differentiation, FAB M0
  • Prevalence: -
  • Inheritance: -
  • Age of onset: -
  • ICD-10: C95.0
  • OMIM: 601626
  • UMLS: C0280141  C0856823
  • MeSH: -
  • GARD: -
  • MedDRA: 10045516

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