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Autosomal recessive spastic paraplegia type 25

Disease definition

Autosomal recessive spastic paraplegia type 25 (SPG25) is a rare, complex type of hereditary spastic paraplegia characterized by adult-onset spastic paraplegia associated with spinal pain that radiates to the upper or lower limbs and is related to disk herniation (with minor spondylosis), as well as mild sensorimotor neuropathy. The SPG25 phenotype has been mapped to a locus on chromosome 6q23-q24.1.


Classification level: Disorder
  • Synonym(s):
    • Autosomal recessive spastic paraplegia-disc herniation syndrome
    • SPG25
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Adult
  • ICD-10: G11.4
  • OMIM: 608220
  • UMLS: C2936860
  • MeSH: C536861
  • GARD: 9582
  • MedDRA: -

Detailed information

Article for general public


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