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Arthrogryposis multiplex congenita

Disease definition

A group of disorders characterized by congenital limb contractures manifesting as limitation of movement of multiple limb joints at birth that is usually non-progressive and may include muscle weakness and fibrosis. This disorder is always associated with decreased intrauterine fetal movement which leads secondarily to the contractures.


Classification level: Group of disorders
  • Synonym(s):
    • AMC
    • Multiple congenital arthrogryposis
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant or Autosomal recessive or X-linked recessive or Not applicable 
  • Age of onset: Neonatal
  • ICD-10: Q74.3
  • OMIM: -
  • UMLS: C2931264
  • MeSH: C536613
  • GARD: 777
  • MedDRA: 10051643
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