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Nephrogenic systemic fibrosis

Disease definition

Nephrogenic systemic fibrosis (NSF) is a rare systemic fibrosing condition observed in renally impaired patients and characterized by a hardening and thickening of the skin with fibrotic plaques or papules, pruritus, joint pain and stiffness, muscle weakness, limitation of range of motion, and yellowed eyes. It is generally associated with administration of gadolinium-based magnetic resonance imaging contrast agents (GBCA) in patients with kidney disease.


Classification level: Disorder
  • Synonym(s):
    • Nephrogenic fibrosing dermopathy
  • Prevalence: -
  • Inheritance: -
  • Age of onset: -
  • ICD-10: -
  • OMIM: -
  • UMLS: C1619692  C3888044
  • MeSH: -
  • GARD: 9725
  • MedDRA: 10067467

Additional information

Further information on this disease

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