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Drug rash with eosinophilia and systemic symptoms

Disease definition

A rare hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6.

ORPHA:139402

Classification level: Disorder
  • Synonym(s):
    • DRESS syndrome
    • Drug reaction eosinophilic systemic syndrome
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: T78.4
  • OMIM: -
  • UMLS: C1142139  C3541994
  • MeSH: -
  • GARD: -
  • MedDRA: 10058919
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