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Acute myeloid leukemia and myelodysplastic syndromes related to radiation

Disease definition

Acute myeloid leukemia and myelodysplastic syndromes related to radiation represent a subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with radiation. The neoplastic cells typically harbor unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. Patients frequently present with multilineage dysplasia and cytopenias 5-10 years after exposure.

ORPHA:164726

  • Synonym(s):
    • AML and myelodysplastic syndromes related to radiation
  • Prevalence: -
  • Inheritance: -
  • Age of onset: -
  • ICD-10: D46
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

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