Orphanet: Hypereosinophilic syndrome

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Hypereosinophilic syndrome

Disease definition

Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage.


Classification level: Group of disorders
  • Synonym(s):
    • HES
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable or Unknown 
  • Age of onset: All ages
  • ICD-10: D47.5
  • OMIM: -
  • UMLS: C1540912
  • MeSH: D017681
  • GARD: 2804
  • MedDRA: 10048643

Detailed information

Article for general public


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