Orphanet: Cherubism

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Disease definition

Cherubism is a rare, self-limiting, fibro-osseous, genetic disease of childhood and adolescence characterized by varying degrees of progressive bilateral enlargement of the mandible and/or maxilla, with clinical repercussions in severe cases.


Classification level: Disorder
  • Synonym(s):
    • CRBM
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant or Autosomal recessive or Not applicable 
  • Age of onset: Childhood
  • ICD-10: K10.8
  • OMIM: 118400
  • UMLS: C0008029
  • MeSH: D002636
  • GARD: 6036
  • MedDRA: 10070535

Detailed information


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