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Ledderhose disease

Disease definition

A rare, benign, superficial fibromatosis disease characterized by single or multiple, uni- or bilateral, fixed, slow-growing, round, firm nodules typically located on the medial portion of the plantar aponeurosis, with no calcification. Patients are often asymptomatic or may present with foot pain, difficulty to walk or stand and, rarely, toe contractures. Histopathology reveals dense fibrocellular tissue with parallel and nodular arrays of fibrocytes and fibrillar collagen with a distinctive cork-screw morphology and no atypia.

ORPHA:199251

Classification level: Disorder
  • Synonym(s):
    • Plantar fibromatosis
  • Prevalence: -
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: M72.2
  • OMIM: -
  • UMLS: C0158360
  • MeSH: C537000
  • GARD: 6873
  • MedDRA: 10035154
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