Orphanet: Sporadic Creutzfeldt Jakob disease

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Sporadic Creutzfeldt-Jakob disease

Disease definition

A subacute fatal neurodegenerative disease belonging to the group of prion diseases, characterized by a clinical triad of dementia, myoclonus, and EEG anomalies, along with neuropathological evidence of neuronal loss, spongiform changes, and astrocytosis. There are three types of CJD: sporadicCJD (sCJD), inherited CJD , and iatrogenic and variant CJD (vCJD).


Classification level: Disorder
  • Synonym(s):
    • Sporadic CJD
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Adult, Elderly
  • ICD-10: A81.0
  • OMIM: 123400
  • UMLS: C0022336
  • MeSH: D007562
  • GARD: 6956
  • MedDRA: 10011384

Detailed information

Article for general public


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