Orphanet: Childhood apraxia of speech

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Childhood apraxia of speech

Disease definition

A rare neurologic disease characterized by impaired ability to execute complex coordinated movements underlying the production of speech, leading to highly unintelligible speech in the absence of muscular or sensory deficits. Initial presentation may be a severe expressive speech delay. Later, characteristic features are inconsistent errors on consonants and vowels in repeated productions of syllables or words, lengthened and disrupted coarticulatory transitions between sounds and syllables, and inappropriate prosody.


Classification level: Disorder
  • Synonym(s):
    • CAS
    • Developmental verbal dyspraxia
    • Speech and language disorder with orofacial dyspraxia
    • Speech-language disorder type 1
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood
  • ICD-10: -
  • OMIM: 602081
  • UMLS: -
  • MeSH: -
  • GARD: 12889
  • MedDRA: -

Detailed information


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