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Focal palmoplantar and gingival keratoderma

Disease definition

Focal palmoplantar and gingival keratoderma is a very rare form of focal palmoplantar keratoderma characterized by painful circumscribed hyperkeratotic lesions on weight-bearing areas of soles, moderate focal hyperkeratosis of palmar pressure-related areas and an asymptomatic leukokeratosis confined to labial- and lingual- attached gingiva. Additional occasional features may include hyperhidrosis, follicular keratosis and extended oral mucosa involvement.


  • Synonym(s):
    • Focal palmoplantar and gingival hyperkeratosis
  • Prevalence: -
  • Inheritance: -
  • Age of onset: Childhood
  • ICD-10: Q82.8
  • OMIM: 148730
  • UMLS: C1835650
  • MeSH: -
  • GARD: 3098
  • MedDRA: -

Additional information

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