Orphanet: Lacrimoauriculodentodigital syndrome

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Lacrimoauriculodentodigital syndrome

Disease definition

Lacrimoauriculodentodigital (LADD) syndrome is a multiple congenital anomaly syndrome characterized by hypoplasia, aplasia or atresia of the lacrimal system; anomalies of the ears and hearing loss; hypoplasias, apalsias or atresias of the salivary glands; dental anomalies and digital malformations.


Classification level: Disorder
  • Synonym(s):
    • LADD syndrome
    • LARD syndrome
    • Lacrimoauriculoradiodental syndrome
    • Levy-Hollister syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Antenatal, Neonatal
  • ICD-10: Q87.8
  • OMIM: 149730
  • UMLS: C0265269
  • MeSH: -
  • GARD: 6848
  • MedDRA: -
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