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Progressive supranuclear palsy-progressive non-fluent aphasia syndrome

Disease definition

PSP-progressive non fluent aphasia (PSP-PNFA) is an atypical variant of progressive supranuclear palsy (PSP; see this term), a rare late-onset neurodegenerative disease. Unlike classic PSP (Richardson syndrome) patients present with an isolated speech production problem years before developing other motor features of PSP.


Classification level: Subtype of disorder
  • Synonym(s):
    • PSP-AOS
    • PSP-PNFA
    • Progressive supranuclear palsy-apraxia of speech syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: G23.1
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -
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