Orphanet: Early onset generalized limb onset dystonia

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Early-onset generalized limb-onset dystonia

Disease definition

A rare movement disorder characterized by involuntary, repetitive, sustained muscle contractions or postures that typically begins in a single limb and, in most individuals, followed by progressive involvement of other limbs and the trunk, typically sparing the cranial and cervical region.


Classification level: Disorder
  • Synonym(s):
    • Dystonia musculorum deformans
    • EOTD
    • Early-onset generalized torsion dystonia
    • Early-onset isolated dystonia
    • Early-onset primary dystonia
    • Early-onset torsion dystonia
    • Idiopathic torsion dystonia
    • Oppenheim dystonia
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Adolescent, Childhood, Adult
  • ICD-10: G24.1
  • OMIM: 128100  602554
  • UMLS: C0013423  C1851945  C3888090
  • MeSH: -
  • GARD: 2027
  • MedDRA: -

Detailed information


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