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Autoimmune lymphoproliferative syndrome with recurrent viral infections

Disease definition

Autoimmune lymphoproliferative syndrome (ALPS) with recurrent viral infections is a rare genetic disorder characterized by lymphadenopathy and/or splenomegaly and recurrent infections due to herpes viruses.


  • Synonym(s):
    • ALPS with recurrent viral infections
    • CEDS
    • Caspase 8 deficiency syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood
  • ICD-10: D47.9
  • OMIM: 607271
  • UMLS: C1846545
  • MeSH: -
  • GARD: 9796
  • MedDRA: -

Additional information

Further information on this disease

Specialised Social Services

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