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Hemolytic disease of the newborn with Kell alloimmunization

Disease definition

A rare hematologic disease characterized by the transfer of maternal alloantibodies against red blood cell antigens of the Kell family to a fetus positive for this antigen across the placental barrier, causing suppression of erythropoiesis with reticulocytopenia and anemia, as well as alloimmune hemolysis. Severe anemia may lead to hydrops fetalis. Significant hyperbilirubinemia is rare in this condition.


Classification level: Disorder
  • Synonym(s):
    • Anti-K HDN
    • Maternal anti-Kell alloimmunization
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: Infancy, Neonatal
  • ICD-10: P55.8
  • OMIM: -
  • UMLS: C0472751
  • MeSH: -
  • GARD: -
  • MedDRA: -
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