Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Tropical spastic paraparesis

Disease definition

Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.


  • Synonym(s):
    • HAM/TSP
    • HTLV-1-associated myelopathy/tropical spastic paraparesis
    • Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis
    • Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis
    • TSP
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: G04.1
  • OMIM: 159580
  • UMLS: C0030481
  • MeSH: -
  • GARD: 8208
  • MedDRA: 10044696

Detailed information


Additional information

Further information on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.