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Fetal cytomegalovirus syndrome

Disease definition

A fetopathy that is likely to occur when a cytomegalovirus (CMV) infected pregnant woman transmits the virus in utero. Children born with congenital CMV infection may present with hepatomegaly, splenomegaly, jaundice, pneumonitis, fetal growth retardation, petechiae, purpura, and thrombocytopenia. Congenital CMV infection can equally result in major neurological sequelae, including microcephaly, intracranial calcifications, sensorineural hearing loss, chorioretinitis, intellectual and motor disabilities, and seizure disorders. CMV disease sequelae caused by a primary infection are usually more severe than those caused by the reactivation of a latent infection.


Classification level: Disorder
  • Synonym(s):
    • Antenatal CMV infection
    • Antenatal cytomegalovirus infection
    • Mother-to-child transmission of cytomegalovirus syndrome
  • Prevalence: 1-5 / 10 000
  • Inheritance: Not applicable 
  • Age of onset: Neonatal, Antenatal
  • ICD-10: P35.1
  • ICD-11: KA62.3
  • OMIM: -
  • UMLS: C0349499
  • MeSH: -
  • GARD: 1480
  • MedDRA: -

Detailed information

General public

  • Article for general public
  • Español (2022) - Asociación Nacional de Personas con Epilepsia-ANPE


ERN produced/endorsed by ERN(s)   FSMR produced/endorsed by FSMR(s)
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.