Orphanet: Spontaneous periodic hypothermia

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Spontaneous periodic hypothermia

Disease definition

A rare neurologic disorder characterized by spontaneous periodic hypothermia and hyperhidrosis in the absence of hypothalamic lesions.


Classification level: Disorder
  • Synonym(s):
    • Episodic spontaneous hypothermia
    • Shapiro syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Unknown 
  • Age of onset: All ages
  • ICD-10: G90.8
  • OMIM: -
  • UMLS: C2931542
  • MeSH: -
  • GARD: 4815
  • MedDRA: -

Detailed information


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