Orphanet: Juvenile amyotrophic lateral sclerosis

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Juvenile amyotrophic lateral sclerosis

Disease definition

Juvenile amyotrophic lateral sclerosis (JALS) is a very rare severe motor neuron disease characterized by progressive upper and lower motor neuron degeneration causing facial spasticity, dysarthria, and gait disorders with onset before 25 years of age.


Classification level: Disorder
  • Synonym(s):
    • JALS
    • Juvenile Charcot disease
    • Juvenile Lou Gehrig disease
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood
  • ICD-10: G12.2
  • OMIM: 205100  602099  614373
  • UMLS: -
  • MeSH: -
  • GARD: 11901
  • MedDRA: -

Detailed information


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