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Metachromatic leukodystrophy, juvenile form

Disease definition

A subtype of Metachromatic leukodystrophy characterized by progressive psychomotor regression with an onset between 30 months and 16 years of age, often beginning with behavioral abnormalities or deterioration of school performance. Further manifestations are ataxia, gait disturbances, reduced deep tendon reflexes, spasticity, seizures, paralysis, dementia, and loss of speech, vision, and hearing, eventually resulting in complete loss of motor and cognitive skills, and decerebration. The rate of deterioration is variable with possible survival up to the third decade of life.


Classification level: Subtype of disorder
  • Synonym(s):
    • Arylsulfatase A deficiency, juvenile form
    • MLD, juvenile form
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: Childhood, Adolescent
  • ICD-10: E75.2
  • ICD-11: 5C56.02
  • OMIM: 250100
  • UMLS: C0751276
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

General public


Disease review articles

Clinical Outcome Assessment (COA)

  • Patient-Centered Outcome Measures (PCOMs)
  • English (2023) - PROQOLIDTM
ERN produced/endorsed by ERN(s)   FSMR produced/endorsed by FSMR(s)
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.