Orphanet: Rheumatic fever

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Rheumatic fever

Disease definition

Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.


Classification level: Disorder
  • Synonym(s):
    • Acute rheumatic fever
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Childhood
  • ICD-10: I00  I01.0  I01.1  I01.2  I01.8  I01.9
  • OMIM: 268240
  • UMLS: C0035436
  • MeSH: D012213
  • GARD: 5699
  • MedDRA: 10039054
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