Orphanet: Autosomal dominant spastic paraplegia type 41

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Autosomal dominant spastic paraplegia type 41

Disease definition

A pure form of hereditary spastic paraplegia characterized by onset in adolescence or early adulthood of slowly progressive spastic paraplegia, proximal muscle weakness of the lower extremities and small hand muscles, hyperreflexia, spastic gait and mild urinary compromise.


Classification level: Disorder
  • Synonym(s):
    • SPG41
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Adolescent, Adult
  • ICD-10: G11.4
  • OMIM: 613364
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

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