Orphanet: Congenital factor II deficiency

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Congenital factor II deficiency

Disease definition

An inherited bleeding disorder due to reduced activity of factor II (FII, prothrombin) and characterized by mucocutaneous bleeding symptoms.


Classification level: Disorder
  • Synonym(s):
    • Dysprothrombinemia
    • Hypoprothrombinemia
    • Prothrombin deficiency
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: All ages
  • ICD-10: D68.2
  • OMIM: 613679
  • UMLS: C0020640  C0272317  C3203356
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

Article for general public


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