Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Kleine-Levin syndrome

Disease definition

Kleine-Levin syndrome (KLS) is a rare neurological disorder of unknown origin characterised by relapsing-remitting episodes of hypersomnia in association with cognitive and behavioural disturbances.


  • Synonym(s): -
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: -
  • Age of onset: Adolescent, Childhood, Adult
  • ICD-10: G47.8
  • OMIM: 148840
  • UMLS: C0206085
  • MeSH: D017593
  • GARD: 3117
  • MedDRA: 10053712

Detailed information


Additional information

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.