Orphanet: Oncogenic osteomalacia

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Oncogenic osteomalacia

Disease definition

A rare paraneoplastic syndrome characterized by renal phosphate wasting and bone demineralization due to a phosphaturic mesenchymal tumor of the mixed connective tissue variant. It causes osteomalacia in adults with bone pain and pathological fractures, and rickets in children.


Classification level: Disorder
  • Synonym(s):
    • Oncogenic hypophosphatemic osteomalacia
    • TIO
    • Tumor-induced osteomalacia
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: M83.8
  • OMIM: -
  • UMLS: C1274103
  • MeSH: -
  • GARD: 9652
  • MedDRA: -
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