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Stevens-Johnson syndrome is a limited form of toxic epidermal necrolysis (see this term) characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area.
ORPHA:36426Classification level: Subtype of disorder
The annual incidence of Stevens-Johnson syndrome is less than 1/1,000,000.
Stevens-Johnson syndrome can be triggered by a drug allergy and, more rarely, by infections or bone marrow transplantation. In 25 to 30% of cases, the cause is unclear.
Management and treatment
Patients should be admitted to an intensive care or burns unit as soon as the diagnosis is suspected.
Reepithelialization is rapid (2-3 weeks).