Orphanet: Chronic granulomatous disease

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Chronic granulomatous disease

Disease definition

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency, mainly affecting phagocytes, which is characterized by an increased susceptibility to severe and recurrent bacterial and fungal infections, along with the development of granulomas.


Classification level: Disorder
  • Synonym(s):
    • CGD
    • Chronic septic granulomatosis
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Autosomal recessive or X-linked recessive 
  • Age of onset: Infancy, Childhood, Adolescent, Adult
  • ICD-10: D71
  • OMIM: 233670  233690  233700  233710  306400  613960
  • UMLS: C0018203
  • MeSH: D006105
  • GARD: 6100
  • MedDRA: 10008906
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