Orphanet: Malignant hyperthermia of anesthesia

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Malignant hyperthermia of anesthesia

Disease definition

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat.


Classification level: Disorder
  • Synonym(s):
    • Hyperthermia of anesthesia
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant 
  • Age of onset: All ages
  • ICD-10: T88.3
  • OMIM: 145600  154275  154276  600467  601887  601888
  • UMLS: C0024591
  • MeSH: D008305
  • GARD: 6964
  • MedDRA: 10020844

Detailed information

Article for general public


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