Orphanet: Pure autonomic failure

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Pure autonomic failure

Disease definition

Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.


Classification level: Disorder
  • Synonym(s):
    • Bradbury-Eggleston syndrome
    • Idiopathic orthostatic hypotension
    • PAF
    • Pure dysautonomia
    • Pure idiopatic dysautonomia
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Adult, Elderly
  • ICD-10: G90.3
  • OMIM: -
  • UMLS: C0393911  C2931939
  • MeSH: C544351  D054970
  • GARD: 10428
  • MedDRA: -
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