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Familial keratoacanthoma

Disease definition

Multiple familial keratoacanthoma (KA) of Witten and Zak is a rare a rare inherited skin cancer syndrome and is characterized by the coexistence of features characteristic of both multiple KA, Ferguson Smith type and generalized eruptive keratoacanthoma (see these terms), such as multiple small miliary-type lesions, larger self-healing lesions, and nodulo-ulcerative lesions .Lesions do not have a predilection for the mucosal surfaces. Transmission is autosomal dominant.

ORPHA:493

Classification level: Disorder
  • Synonym(s):
    • Hereditary keratoacanthoma
    • Multiple keratoacanthoma
  • Prevalence: -
  • Inheritance: Autosomal dominant 
  • Age of onset: All ages
  • ICD-10: L85.8
  • OMIM: -
  • UMLS: C0546476
  • MeSH: -
  • GARD: -
  • MedDRA: -
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