Orphanet: Li Fraumeni syndrome

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Li-Fraumeni syndrome

Disease definition

A rare, inherited, cancer predisposition syndrome characterized by the early-onset of multiple primary cancers including breast cancer, soft tissue and bone sarcomas, brain tumors, adrenal cortical carcinoma (ACC), leukemias, and other cancers.


Classification level: Disorder
  • Synonym(s): -
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant 
  • Age of onset: All ages
  • ICD-10: D48.9
  • OMIM: 151623  609265  609266
  • UMLS: C0085390
  • MeSH: D016864
  • GARD: 6902
  • MedDRA: 10066795

Detailed information


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