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Thrombotic thrombocytopenic purpura

Disease definition

An aggressive and life-threatening form of thrombotic microangiopathy (TMA) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of a congenital (cTTP) and acquired, immune-mediated (iTTP) form.


Classification level: Disorder
  • Synonym(s):
    • Moschcowitz disease
    • TTP
  • Prevalence: Unknown
  • Inheritance: Autosomal recessive or Multigenic/multifactorial 
  • Age of onset: All ages
  • ICD-10: M31.1
  • ICD-11: 3B64.14
  • OMIM: 274150
  • UMLS: C0034155
  • MeSH: D011697
  • GARD: -
  • MedDRA: 10043648

Detailed information

General public


Disease review articles

ERN : produced/endorsed by ERN(s)
FSMR : produced/endorsed by FSMR(s)
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