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Primary membranoproliferative glomerulonephritis

Disease definition

Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes.


Classification level: Disorder
  • Synonym(s):
    • MPGN
    • Mesangiocapillary glomerulonephritis
  • Prevalence: 1-5 / 10 000
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: N00.5
  • OMIM: 305800  609814  614809  615008
  • UMLS: C0017662
  • MeSH: D015432
  • GARD: 11982
  • MedDRA: 10018370
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