Orphanet: Laron syndrome

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Laron syndrome

Disease definition

Laron syndrome is a congenital disorder characterized by marked short stature associated with normal or high serum growth hormone (GH) and low serum insulin-like growth factor-1 (IGF-I) levels which fail to rise after exogenous GH administration.


Classification level: Disorder
  • Synonym(s):
    • Complete growth hormone insensitivity
    • GH receptor deficiency
    • Growth hormone receptor deficiency
    • Laron-type dwarfism
    • Primary GH insensitivity
    • Primary GH resistance
    • Primary growth hormone insensitivity
    • Primary growth hormone resistance
    • Short stature due to growth hormone resistance
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: E34.3
  • OMIM: 262500
  • UMLS: C0271568
  • MeSH: D046150
  • GARD: 6859
  • MedDRA: -
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