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CANOMAD syndrome

Disease definition

A rare chronic immune-mediated polyneuropathy characterized by a progressive disabling neuropathy with marked gait disturbance primarily due to sensory ataxia with concurrent cranial neuropathies (internal or external ophthalmoplegia, dysphagia, dysarthria, or facial weakness) and anti-disialosyl IgM antibodies.


Classification level: Disorder
  • Synonym(s):
    • CANDA syndrome
    • Chronic ataxic neuropathy-ophthalmoplegia-IgM paraprotein-cold agglutinins-disialosyl antibodies syndrome
    • Chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies
  • Prevalence: <1 / 1 000 000
  • Inheritance: -
  • Age of onset: Adult, Elderly
  • ICD-10: G61.8
  • OMIM: -
  • UMLS: C2931684
  • MeSH: C537980
  • GARD: 9778
  • MedDRA: -

Detailed information


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