Orphanet: Pseudohypoaldosteronism type 2

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Pseudohypoaldosteronism type 2

Disease definition

A rare genetic form of hypertension characterized by hyperkalemia, mild hyperchloremic metabolic acidosis, normal or elevated aldosterone, low renin, with normal renal glomerular filtration rate (GFR).


Classification level: Disorder
  • Synonym(s):
    • Chloride shunt syndrome
    • Familial hyperkalemic hypertension
    • Gordon hyperkalemia-hypertension syndrome
    • Hyperkalemia-hypertension syndrome, Gordon type
    • Hypertensive hyperkalemia
    • Mineralocorticoid resistant hyperkalemia
    • PHA2
    • PHAII
    • Spitzer-Weinstein syndrome
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant or Autosomal recessive 
  • Age of onset: All ages
  • ICD-10: I15.1
  • OMIM: 145260  614491  614492  614495  614496
  • UMLS: C1449844
  • MeSH: -
  • GARD: 4553
  • MedDRA: -

Detailed information


The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.