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Central precocious puberty

Disease definition

Central precocious puberty (CPP), also referred to as gonadotropin dependent precocious puberty, is an endocrine-related developmental disease characterized by the onset of pubertal changes, with development of secondary sexual characteristics and accelerated growth and bone maturation, before the normal age of puberty (8 years in girls and 9 years in boys).


Classification level: Disorder
  • Synonym(s):
    • CPP
    • Gonadotropin-dependant precocious puberty
  • Prevalence: Unknown
  • Inheritance: Not applicable or Autosomal dominant 
  • Age of onset: Infancy, Childhood
  • ICD-10: E22.8
  • ICD-11: 5A60.3
  • OMIM: 176400  615346
  • UMLS: C0342543
  • MeSH: -
  • GARD: -
  • MedDRA: -
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