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Acquired generalized lipodystrophy

Disease definition

A rare lipodystrophic syndrome characterized by loss of adipose tissue, and is a syndrome of insulin resistance that leads to increased cardiovascular risk. Acquired generalized lipodystrophy is related to a selective loss of subcutaneous adipose tissue occurring exclusively at the extremities (face, legs, arms, palms and sometimes soles).


Classification level: Disorder
  • Synonym(s):
    • Acquired lipoatrophic diabetes
    • Lawrence syndrome
    • Lawrence-Seip syndrome
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: E88.1
  • OMIM: -
  • UMLS: C0271693  C3665770
  • MeSH: -
  • GARD: 12603
  • MedDRA: -

Detailed information


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