Orphanet: X linked congenital generalized hypertrichosis

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

X-linked congenital generalized hypertrichosis

Disease definition

X-linked congenital generalized hypertrichosis is an extremely rare type of hypertrichosis lanuginosa congenita, a congenital skin disease, which is characterized by hair overgrowth on the entire body in males, and mild and asymmetric hair overgrowth in females. It is associated with a mild facial dysmorphism (anterverted nostrils, moderate prognathism), and, in a kindred, it was also associated with dental anomalies and deafness.


Classification level: Subtype of disorder
  • Synonym(s):
    • Congenital generalized hypertrichosis, Macias-Flores type
    • Macias Flores-Garcia Cruz-Rivera syndrome
  • Prevalence: -
  • Inheritance: X-linked dominant 
  • Age of onset: -
  • ICD-10: Q84.2
  • OMIM: 307150
  • UMLS: C2931836
  • MeSH: C538388
  • GARD: 2863
  • MedDRA: -
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.